
Fundamental Biology
Traditional genomic profiling alone often fails to capture the full spectrum of cancer's functional biology. Considering most targeted treatments act on proteins, not genes or transcripts, proteomic and phosphoproteomic analyses will be critical in identifying actionable targets. Tumor progression is driven by dysregulated protein signaling networks, which may not be evident through DNA or RNA sequencing alone. A comprehensive multi-omic approach, combining genetic, proteomic, and functional data, will be essential to fully characterize tumors and inform individualized therapeutic strategies.
Tumors adapt through Darwinian selection, developing into diverse sub-clonal populations that respond to environmental pressures, evade immune detection, and acquire resistance to therapies. This evolutionary process highlights the need for dynamic and adaptable combination treatment strategies that consider not only molecular complexity, but also for the tumor microenvironment.


Our Approach
